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2 Trial results confirmed that the risk of a major adverse cardiovascular event (MACE) decreased with the use of RYBELSUS as compared to a placebo, when used concomitantly with standard of care treatments for diabetes and cardiovascular disease

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Examples of medications that increase your risk of seizures include: Tricyclic antidepressants (TCAs) such as Elavil (amitriptyline) and Tofranil (imipramine) Antipsychotic medications such as Clozaril (clozapine) Stimulants such as Adderall (mixed amphetamine salts) Opioids such as Ultram (tramadol) Flexeril (cyclobenzaprine) Benadryl (diphenhydramine) Theo-Dur (theophylline ER) Medications broken down in your liver Bupropion XL is metabolized (broken down) in your liver by the CYP2B6 enzyme