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Oct 2017;114:469-473

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Diet diversity, gut microbiome differences, genetic predisposition, and varying insulin resistance patterns across regions can materially affect both efficacy and tolerability of GLP-1 and triple agonists

AAV2-GDNF: Gene Therapy to Deliver Neuroprotective Growth Factor Mechanism: AAV2-GDNF is an investigational gene therapy that delivers the gene encoding glial cell line-derived neurotrophic factor (GDNF) directly into an important brain region called the putamen, using an adeno-associated virus serotype 2 (AAV2) vector

"This was very concerning and something we needed to address and communicate to the public like we are doing right now," Harter said