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Boxed warning and who should not use these medicines Both semaglutide and tirzepatide carry a boxed warning about thyroid C-cell tumors seen in rodent studies
Starting doses are small (10 units for 0.25 mg) but still measurable
In patients with T2DM, GLUT-4 expression is markedly reduced, and GLP-1 mediated up-regulation of GLUTs, especially in cardiomyocytes, helps preserve their integrity [52]
PMID: 41433034, PMCID: PMC12728728, DOI: 10.1001/jamacardio.2025.4824.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHospital admissionSerious adverse eventsRandomized clinical trialsEstablished CV diseaseCV diseaseSemaglutide groupRate of hospital admissionsAdverse eventsClinical trialsReduction of hospital admissionsDuration of hospital stayImpact of semaglutideBody mass indexTotal hospital admissionsEstablished cardiovascular diseaseEffect of semaglutideCV risk reductionOnce-weekly semaglutideAssociated with significant reductionsMain OutcomesMass indexPlacebo groupPatient yearsTotal hospitalHospital stay FDA Cardiovascular Indication Expansion and Dispensing of Semaglutide/Tirzepatide in CVD Patients With Overweight/Obesity Do D, Murugiah K, Sawano M, Cartwright B, Rodriguez P, Gratzl S, Curtis L, Jastreboff A , Lu Y, Stucky N
The mechanism difference (tissue repair via angiogenesis vs gene expression modulation) is exactly what makes them complementary in combination formulations rather than substitutes for each other
