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The covalent adduct between the (2 S ,3 S )- t -ES moiety in these generated inhibitors and active site cysteines is expected to be the mechanism of irreversible inhibition 20

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Gromada J, Ma X, Hoy M et al (2004) ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cells

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