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identified specific point mutations in the paternal allele of MAGEL2 in four individuals with PWS, where weight gain was a prominent feature along with muscle weakness, developmental delays, and hypogonadism ( Kanber and colleagues described a patient with deletions in MKRN3, MAGEL2, and NDN, exhibiting only obesity, developmental delay, and a high pain threshold as the primary clinical criteria for PWS ( The SNORD116 cluster is crucial in the PWS phenotype
Autism ResearchlJ: Official Journal of the International Society for Autism Research, 10(4), 608619
Monitoring Thyroid Function During GLP-1 Weight Loss Treatment Starting tirzepatide or any GLP-1based therapy does not automatically require levothyroxine adjustment, but it does require baseline thyroid labs and follow-up monitoring at 68 week intervals for the first three months
Head-to-head Phase 3 superiority over semaglutide 1 mg in DREAMS-3
14211442, doi:10.1007/s00394-013-0511-0, PMID 23508457
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