Since many metabolites of phase I are too lipophilic to be retained in the kidney tubules, a subsequent conjugation reaction with an endogenous substrate, such as glucuronic acid, acetic acid, sulfuric acid or an amino acid, results in formation of more polar and hydrophilic compounds that are sufficiently polar to be excreted by the kidneys
GNF triggered ferroptosis in TGF-1-treated melanoma cells by activating the p53/SLC7A11/GPX4 axis (Wang et al., 2020)
& Taegtmeyer, H
Antioksidan ini bekerja dengan membantu tubuh melawan radikal bebas yang dapat mempercepat penuaan
In contrast, long chain fatty acids are bound to plasma proteins and require transporter proteins for uptake into cells and mitochondria (Schnfeld and Wojtczak, 2016)
Health Effects 10.1787/9789264071001-en (OECD Publishing, 2002)