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however, interviews were conducted with 20+ KOLs in the 7MM

What weve seen in a real-world setting is those who discontinue particularly early and patients who stay on lower maintenance dosages are quite unlikely to see the weight reductions that are reported in randomized trials

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program

Plausible mechanisms include weight lossmediated benefit, metabolic regulation and direct antiinflammatory effects, but current data are limited by small samples and uncontrolled designs

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