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Among these, compounds 53 (IC 50 = 4 nM) and 54 (IC 50 = 10 nM) exhibited high DPP-4 inhibitory activities, good efficacy, and selectivity in an oral glucose tolerance test in ICR mice (Figure 7)

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The large molecular size of GLP-1 peptides makes transdermal delivery highly implausible without advanced technology not present in consumer products

Eating or drinking too soon after dosing is the most common one