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"We just don't have data on the use of GLP-1 agonists in a pregnant population so we always err on the side of caution in terms of looking at the risks of birth defects," Ashton said

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By total search volume, semaglutide is the most-searched peptide-based compound

Semaglutide mimics the effects of a natural hormone in your body called GLP-1 (glucagon-like peptide-1)

Researchers are also developing drugs that block the immunogenic form of the peptides and exploring an immune tolerization approach to reprogram the immune response to gluten

Researchers studying GCGR-driven energy expenditure or hepatic glucose output in cell models often use retatrutide alongside the other two as reference compounds to isolate the contribution of each receptor