GLP-1s are designed to suppress appetite, but nursing mothers should be consuming more calories, not less, to support milk production
However, individual cases of thyroid nodule development or changes in thyroid antibody levels have been reported anecdotally, though causation has not been established in controlled research
More significantly, its December 23, 2014 approval at higher doses as Saxenda for chronic weight management marked the first GLP 1 agonist specifically indicated for long term obesity treatment
Using a robust new-user, active-comparator design across 10 international databases, the investigators compared major cardiovascular outcomes, including 3-point MACE (myocardial infarction, stroke, cardiovascular death) and 4-point MACE (adding heart failure hospitalization)
Tirzepatide (Mounjaro, Zepbound) may be more effective than injectable semaglutide (Ozempic, Wegovy)
Some participants described initial concerns about self-injecting and their ability to tolerate the needles, particularly those who were not self-administering insulin already
