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Tesamorelin (Egrifta, Egrifta SV) is FDA-approved for the treatment of HIV-associated lipodystrophy (excess abdominal fat in HIV-positive patients on antiretroviral therapy)

When the light signal is positive, the SCN secretes gamma-amino butyric acid, responsible for the inhibition of the neurons that synapse in the paraventricular nucleus (PVN) of the hypothalamus, consequently the signal to the pineal gland is interrupted and melatonin is not synthesized

Zhang, J., Ma, X