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As a medical student, this is one of those moments in pharmacology where you realise medicine is still full of surprises. Mohammad Junaid Rain, MBBS 2nd Year What Makes Tirzepatide Results So Remarkable

The advent of incretin-based therapies and the expansion to multi-receptor agonist peptides targeting glucagon-like peptide 1 (GLP1), glucose-dependent insulinotropic polypeptide (GIP), glucagon, and amylin receptors has transformed obesity treatment, demonstrating average weight loss of more than 20% in humans and improvements in a broad range of obesity-related comorbidities

And in higher amounts, GLP-1 also interacts with the parts of the brain that reduce appetite and signal a feeling of fullness

Oliveira AL, Viegas MF, da Silva SL, Soares AM, Ramos MJ, Fernandes PA (2022) The chemistry of snake venom and its medicinal potential

The thigh is a good alternative if you want to rotate sites

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