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Nature 526:715718 Sansom OJ, Reed KR, Hayes AJ, Ireland H, Brinkmann H, Newton IP et al (2004) Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Yadav SK, Rai SN, Singh SP

Future direction and relevance for gut-brain interventions More broadly, our review on the modulatory role of ghrelin and GLP-1 in reward processing adds to the growing evidence on the potential of gut-based interventions for motivational and emotional dysfunctions across a range of mental and metabolic disorders (Cryan et al., 2019

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Appl Catal B Environ 48:101111

The main findings so far are dose-dependent weight loss in phase 2 studies, frequent gastrointestinal side effects, and ongoing questions about long-term safety, eligibility, and approval