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In over half of participants calprotectin levels lowered by 10%, though its unclear whether this is enough to mitigate the side effects of PPIs

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As an additional test of the specificity of the effect, we find that the decrease in glutamate brought by acivicin could be rescued by administration of pyroglutamate (5-oxoproline), a downstream metabolite in the glutathione pathway that is a precursor of glutamate ( SI Appendix , Fig

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