Dietary sphingomyelin (SM) supplementation also remarkably decreased the atherosclerotic lesion area in the aortic arch in chow-fed ApoE / mice, reduced serum TMAO levels in C57BL/6 mice, and did not affect circulating SM levels or increase AS in ApoE / mice fed a HFD (Chung et al., 2017)
If you're currently taking a compounded version of semaglutide or tirzepatide, this change won't happen overnight
Tuppen HAL, Blakely EL, Turnbull DM, Taylor RW
J., Sabbagh, J
Wegovy Dosing Schedule Month 1 (Weeks 1-4): 0.25 mg weekly Month 2 (Weeks 5-8): 0.5 mg weekly Month 3 (Weeks 9-12): 1 mg weekly Month 4 (Weeks 13-16): 1.7 mg weekly Month 5+ (Week 17+): 2.4 mg weekly (maintenance dose) Youll reach the maximum dose after about 16-20 weeks
Within each panel, the groups total, stop, dipeptidyl peptidase-4 inhibitor (DPP4i), and sodium glucose cotransporter-2 inhibitor (SGLT2i) are compared