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The most common early side effects of semaglutide, tirzepatide, or retatrutide include: Nausea or bloating Constipation Fatigue or low energy Mild dehydration Each of these symptoms can make physical intimacy less appealing

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Originally approved for diabetes, these medications quickly became the most powerful pharmaceutical weight-loss option in history

You may have noticed the list of potential side effects for semaglutide looks similar to the potential symptoms of a UC flare

Theres some scientific rationale supporting this possibility, as it has been hypothesized that GLP1 agonists may decrease rewarding/reinforcing effects of alcohol and other drugs of abuse