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[25] This appraisal is useful context for understanding how similar agents are evaluated in the UK, but it does not apply directly to retatrutide, which remains unlicensed

3.6 Potential Microbiome Changes GLP-1 receptor agonists alter: Gastric motility Transit time Food intake patterns Emerging research suggests that weight loss and altered dietary intake may influence gut microbiota composition. At present, there is insufficient evidence to conclude that GLP-1 drugs independently cause clinically significant microbiome-mediated nutrient depletion

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This rigorous vetting process helps ensure that bariatric surgery is undertaken by patients most likely to reap its benefits