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The basic principle causing the radiation-induced toxicity is the excessive generation of reactive oxygen species (ROS) due to the radiolysis of cellular water, which in turn oxidizes the critical biomolecules such as lipid, protein, and DNA [36,37,38,39]

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17 Conversely, in a recent large meta-analysis of over 15,000 patients, despite being the safest MRA, finerenone showed limited evidence of efficacy in patients with HFrEF