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Topical applications appear generally well-tolerated in small studies, but systemic safety, long-term effects, and drug interactions remain inadequately characterized

7 In the absence of Wnts, the transmembrane receptors FZD and LRP5/6 are located on the plasma membrane separately

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And in the eyes, tiny vessels weaken, light itself becoming clouded through retinopathy

Sandsdal RM, Juhl CR, Jensen SBK, Lundgren JR, Janus C, Blond MB, et al