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And if twice-daily dosing failed to produce the effect that once-daily morning dosing did, the intuition that timing failures can be solved by adding another dose finds no support in the only data available

(Netherlands: Springer)

Clinical trials as mentioned by the research studies have used weight-based dosing (for example, 0.03 mg/kg twice daily in a proof-of-concept surgical trial)

Sep 1993;42(9):1217-1222

Ethics statement All procedures involving human participants in this study were pproved by the Research Ethics Committee of the First Affiliated Hospital of USTC.All patients included in the present study signed informed consent.All animal xperiments were approved by the Animal Management Committee of the First ffiliated Hospital of USTC

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