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They also identified a characteristic deoxycholic acid (DCA) decrease-CDCA increase pattern, suggesting this bile acid fingerprint as an independent risk factor for hyperandrogenemia in lean PCOS ( Aberrant bile acid metabolism contributes to the pathogenesis of PCOS through intricate molecular mechanisms
Proc Natl Acad Sci 102:21742179
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Amentoflavone promotes ferroptosis by regulating reactive oxygen species (ROS)/5AMP-activated protein kinase (AMPK)/mammalian target of rapamycin (mTOR) to inhibit the malignant progression of endometrial carcinoma cells
rather, use of such a strategy would subject more patients to overtreatment without much added benefit, leading to increasing healthcare costs as patients are often treated for acute APAP hepatotoxicity in medical intensive care units to ensure close monitoring of vital signs and the ability for frequent neurologic assessments
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