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Additionally, Fas-mediated apoptosis of erythroid precursors in low grade myelodysplastic syndromes is linked to ER via caspase-8-mediated cleavage of B-cell receptor-associated protein 31 (BAP31), which is an ER-associated chaperone and quality control protein

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534,535 Combination therapy, starting with a single agent and titrating to the maximum tolerated dose, may enhance efficacy when pain control is inadequate, with recent studies suggesting superior pain relief compared to monotherapy