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Alternatively, when isotopic labeling is infeasible, unlabeled metabolomics and/or targeted biochemical assays can detect correlative changes in total off-target metabolite levels, while epistasis studies with multiple genetic and/or pharmacological manipulations can allow causal assessment of whether probable metabolic off-targets are required for given physiological or behavioral readouts

Hennessy et al

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J Biol Chem (2018) 293(32):1241528

GHKCu has been shown to increase collagen and elastin, improve skin thickness, and reduce wrinkle volume, giving skin a firmer, more lifted, microsculpted look with consistent usewithout the irritation of traditional actives