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Although the insulinotropic activity of GLP-1 was identified over 30 years ago, the short half-life of native GLP-1 (approximately 2 min)attributed to rapid enzymatic degradation by dipeptidyl peptidase-IVimpeded its early therapeutic application in T2DM (111)

10.1186/s41983-022-00452-2 Egypt J Neurol Psychiatry Neurosurg

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To our knowledge, however, there are currently no reports describing how GLP-1 receptor agonist treatment modulates the expression of BDNF, leptin, ghrelin, NPY, -MSH, or AgRP in the context of MC4R deficiency

Rizza, R