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The mRNA expression of the CAT gene in the placenta of gestational diabetic pregnant women was found to be higher in comparison to that in normal pregnant women [74]
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This bidirectional relationship is notable because GLP-1 itself activates the hypothalamicpituitaryadrenal (HPA) axis, increasing circulating cortisol in humans and corticosterone in rodents
LOX-1 is responsible for binding, being internalized, and proteolytically degrading oxLDL but not acetylated LDL, and thus mediates foam cell formation in atherosclerotic plaques (35)
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