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Accession Number: P36970

Additionally, a meta-analysis of multiple randomized, controlled trials confirmed that tesamorelin treatment significantly lowered visceral fat area and trunk fat, reduced hepatic fat, and was associated with a statistically significant increase in lean body mass, supporting its clinical effect on fat distribution and muscle preservation

Of note is that GSTP1 also attenuated caspase 3 activity induced by the positive control tamoxifen by 50% (Supplementary Figure S4)

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10.3389/fnins.2021.646678 77

However, when produced in excess, ROS can overwhelm cellular antioxidant defenses, leading to oxidative stress and the disruption of essential biomolecules, including nucleic acids, proteins, and membrane lipids