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7 How GLP-1 drugs may reshape addiction pathways GLP-1 RAs interact with the mammalian mesolimbic reward system and have been proposed to modulate dopaminergic signaling in circuits involving the ventral tegmental area, nucleus accumbens, and other reward-related regions, thereby reducing the reinforcing value of food and some substances in preclinical models

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Y., Granda, R., Mohan, S., Kuipers, J., Baylink, D., & Veldhuis, J