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That trial supports a 2024 FDA label expansion making semaglutide indicated for cardiovascular risk reduction in adults with overweight or obesity and prior CV disease

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The results demonstrated a significant reduction in composite renal outcomes, largely driven by the improvements in glycemic control and reductions in SBP, which in turn led to a decreased risk of eGFR decline and cardiovascular events [110]

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These effects collectively improve postprandial glucose excursions and reduce fasting blood glucose levels in patients with type 2 diabetes