The strong inhibitory effects of YM-254890 on F/I-stimulated GLP-1 secretion present a challenge for interpreting hGPR17L-mediated Gq signaling contributions to regulation of GLP-1 secretion
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Further research has found that mitochondria-associated fission protein, and mitochondria autophagy-related proteins (PINK1, BNIP3, and NIX) were elevated and apoptosis was increased in high glucose and hypoxia-induced human retinal pigment epithelial cell (ARPE-19) model
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