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Three dual agonists (peptide 15, MEDI0382 and SAR425899) and one triple agonist (peptide 20) were evaluated at GLP-1R and GCGR, relative to the native peptidic ligands (GLP-1 and glucagon)

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[36] Ibid

Semaglutide was superior to placebo in terms of the trials primary endpoint, mean percentage change in BMI at week 68 (16.1% decrease vs 0.6% increase)

The reported prevalence rates for these symptoms are as follows: sleep disturbances (39%), hyperphagia (23%), disinhibition (13%), hallucination (13.4 to 41%) and delusion (51%) (Keene and Hope, 1998

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