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184,185 Upregulated USP20 expression in oxaliplatin-resistant HCC cells is associated with poor prognosis, while genetic knockdown or pharmacological inhibition of USP20 can trigger ferroptosis and increase the sensitivity of HCC cells to oxaliplatin both in vitro and in vivo

Although DPP-4 inhibitors do not cross the BBB under normal conditions (the pharmacokinetic feature may prevent their repurposing use in neurodegenerative diseases), the permeability of BBB is increased in neurodegenerative diseases, so molecules otherwise unable to cross BBB could enter into CNS in these conditions (103)

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