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B6 deficiency can cause irritability, fatigue, and difficulty concentrating, so maintaining adequate levels is important during treatment

Research on adaptive thermogenesis shows that individuals who lose substantial weight experience metabolic adaptations where the body becomes more energy-efficient and generates less heat relative to body size

Pair with a side salad to boost fibre

However, stopping too early may lead to regaining weight, so providers usually recommend ongoing use alongside lifestyle changes

We label the strength of evidence and flag estimates as estimates never as clinical fact

These expression patterns are summarized in Table 1