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The function and mechanism of lactate and lactylation in tumor metabolism and microenvironment

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Furthermore, no clinical trials of ferroptosis-targeted monotherapies or combinations exist for RCC, largely due to insufficient preclinical validation in patient-derived models [e.g., patient-derived xenografts (PDXs) and organoids]

In diabetes, reduced GPx in kidneys exacerbates nephropathy, with oxidative damage fueling complications

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