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They lack long-term data and direct comparisons

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If a dose is missed, skip that dose and take the next dose the following day

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(2024) conducted a retrospective study with data collected throughout 2020 to assess the utilization of appropriate laboratory testing related to the diagnosis of acute pancreatitis. The authors were particularly interested in the overuse of amylase testing or amylase and lipase testing together when lipase testing alone would have been sufficient for AP diagnosis