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Therefore, in the battle against biofilms, it is crucial to convert macrophages from the immunosuppressive M2 type to the antimicrobial M1 type (Lei et al., 2019)

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Mol Cell Biochem 337(12):223237 Shukla GS, Shukla A, Potts RJ, Osier M, Hart BA, Chiu JF (2000) Cadmium-mediated oxidative stress in alveolar epithelial cells induces the expression of gamma-glutamylcysteine synthetase catalytic subunit and glutathione S-transferase alpha and pi isoforms: potential role of activator protein-1