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In addition to the Leu198Leu genotype in the GPx1 gene, the Ala16Ala genotype in the manganese superoxide dismutase ( MnSOD ) gene, the most significant enzyme that protects against ROS in the human body [90], was also associated with an increased risk of breast cancer [91]

7G), in accordance with the well-documented effect of drugs on the gut microbiome 41,42

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Science 342 , 373377 (2013)

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Numerous studies have raised questions regarding the behavior of HQ as a tyrosinase inhibitor 26,27 , and most of them characterized HQ as a competitive inhibitor 24,43,44,45