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A higher number of affected LNs is associated with an increased risk of cancer recurrence and a worsened survival rate in many cancer types, including melanoma (8, 9), breast cancer (10, 11), head and neck cancer (12), prostate cancer (13, 14), and colon cancer (15, 16)

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In fact, the contribution of CYP2D6 to MDMA metabolism has been reported to be less than 30% (Segura et al., 2005)

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doi: 10.1016/j.berh.2014.10.016 5 Martinez-PratLNissenMJLamacchiaCBentowCCesanaLRoux-LombardPet al