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Apremilast (Otezla): A New Oral Treatment for Adults With Psoriasis and Psoriatic Arthritis

Starting dose: 2.5 mg once weekly (subcutaneous injection) Dose escalation may occur based on physician recommendation Administer on the same day each week Can be taken with or without meals Injection sites: abdomen, thigh, or upper arm Follow medical guidance strictly for titration

Solid solution compositions were prepared by mixing appropriate amounts of powders using a rotary mill (CAPCO Test Equipment 12VS, Ipswich, UK) with SiC media for 24 h in ethanol

Animal studies are promising, but the strongest human evidence is for corneal wound healing

The studies are predominantly open-label, randomized trials conducted across multiple countries including China, USA, UK, Egypt, and Slovenia

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