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Frontiers inendocrinology, 13, 838410
In addition, combining MAP and NE requirements to define responsiveness may be inappropriate in observational data since the desired MAP may vary in the acute phase based on organ perfusion signs
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In the SOUL trial (Semaglutide cardiOvascular oUtcomes trial) just published in May 2025, 9650 participants 50 years of age or older who had T2D with a HbA1c of 6.5 to 10.0%, and had known atherosclerotic cardiovascular disease, chronic kidney disease, or both to receive either once-daily oral semaglutide (maximal dose, 14 mg) or placebo, in addition to standard care (5)
