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95% CI, 0.2-0.44) and complex HS cyst repairs (HR = 0.36

Seo and Choi, 2021)

doi: 10.2337/db08-0958 131 NauckMAHeimesaatMMBehleKHolstJJNauckMSRitzelRet al

This results in elevating ROS and oxidative damage ultimately inducing early mitochondrial failure in T cells

Opportunities for progress include rational brain-exposure design with efflux avoidance, development of microglia-directed delivery systems, and incorporation of human target-engagement biomarkers into early-phase studies

Even though observational studies have shown some association between BS and microvascular complications, the RCTS comparing surgery to medical therapy for DM thus far have not establish a significant impact of BS in improving microvascular complications or delaying the progression of microvascular disease with DM