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Future risk factor analysis of autism spectrum disorders should include consideration of multiple biomarkers of nutrients involved in pathways linked with the -glutamyl cycle and the interaction of genotype with nutritional status

Because L-Citrulline largely bypasses first-pass liver metabolism (where some L-Arginine is broken down before reaching the bloodstream), research suggests that L-Citrulline may raise plasma L-Arginine levels more efficiently, gram for gram, than supplementing L-Arginine directly

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Similarly, undiagnosed or poorly controlled psychiatric conditionsespecially binge eating disorder or depressioncan impair treatment outcomes