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Therefore, GLP-1 receptor (GLP-1R) agonists (GLP-1RAs) are recommended as early and ongoing treatment options for patients with type 2 diabetes mellitus (T2DM) in the clinical practice guidelines provided by the American Association of Clinical Endocrinologists and the American Diabetes Association/European Association for the Study of Diabetes (19,20)

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While cagrilintide activates amylin receptors to reduce appetite and slow gastric emptying, semaglutide stimulates GLP-1 receptors to enhance insulin secretion, suppress glucagon, and promote satiety through distinct neural pathways