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Chandys hypothesis, that the rapid onset of the repairing processes induced by B12 shots might overwhelm the system and temporarily cause a worsening in symptoms, similar to the Jarisch-Herxheimer reaction in those treated for Lyme disease

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For instance, ACOs participating in the BASIC track's glide path may elect to remain in Level A (if participation in Level A was previously elected), or to advance to higher levels of risk and reward along the glide path

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