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Amsterdam: European Medicines Agency (2024)

Additionally, some participants experienced dose-dependent increases in heart rate, which peaked at 24 weeks and declined thereafter

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Levine LA, Dimitriou RJ

PD-0200347, an 2 ligand of the voltage gated calcium channel, inhibits in vivo activation of the Erk1/2 pathway in osteoarthritic chondrocytes: a PKC dependent effect