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While the BBB serves as a barrier to restrict the passage of molecules, the integrity and function of the BBB can be compromised by disease states, disease-caused inflammation, and immune responses in the brain [1, 3, 9], or even systemic infection and inflammation [10] resulting in BBB disruption and greater BBB penetration [11]

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Frequently Asked Questions About IGF-1 LR3 1mg IGF-1 LR3 differs from native IGF-1 (70 amino acids) through two modifications: a 13-amino acid N-terminal extension peptide and the substitution of glutamic acid at position 3 with arginine (Glu3 to Arg3, hence 'R3' in the name), resulting in an 83-amino acid protein with a molecular weight of 9,111 Da compared to native IGF-1's 7,649 Da

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