Mitochondrial depolarization was normalized to dimethyl sulfoxide control (0%) and positive control FCCP (carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone
However, an increasing number of research studies are demonstrating that these substances also have neuroprotective effects in neurodegenerative diseases, mental disorders, and other brain conditions
Questionnaires to assess eating behaviour, food preference and food intake Eating behaviour Eating behaviour will be assessed by using a Slovenian translation of the Three-Factor Eating Questionnaire (TFEQ-R18) at visit 1 and visit 8 [23]
All values are presented as mean SD, unless otherwise stated
They are not approved for human use, medical treatment, or self-administration
In support of this hypothesis, our MS interactome indicates the association of active GLP-1R with a range of factors involved in lipid metabolism, including lipases and regulators of lipase transfer to lipid droplets such as Mest 76 and Copb1 77 , lipid metabolising enzymes including TMEM120A 78 , Acsl4 79 , Fads1 80 , Chp1 81 , Cds2 82 , and Apgat4 83 , and mitochondrial FAO and ketone body enzymes (HADHA/B 84 , Bdh1 85 ), as well as the ER/lipid droplet small GTPase Rab18 86 , several subunits of the mitochondrial ATP synthase, the respiratory chain subunit SDHA, and the FAO-fuelled plasma membrane Na + /K + pump 87
