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Studies have documented decreased deposition of amyloid-beta (A) plaques and lower levels of hyperphosphorylated tau, the two defining neuropathological hallmarks of this disease ( 4.2 Parkinsons disease models Semaglutide has demonstrated significant neuroprotective potential in models of Parkinsons disease (PD)

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Clinical Trial Insights In SURMOUNT-1 and SURPASS trials, Mounjaro showed: Up to 22.5% body weight reduction in non-diabetic obese patients Greater HbA1c reductions vs Ozempic and insulin in diabetics Reference : Tirzepatide as Compared with Semaglutide for the Treatment of Obesity Reference : mounjaro.lilly.com/hcp/a1c-weight FDA approved Mounjaro for Type 2 Diabetes in 2022, and later for weight loss under the brand Zepbound in Nov 2023 (US)