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The groups below have higher risk and are usually flagged in case reports and clinical commentary

In addition, endothelial dysfunction and initiation of atherogenesis are known to trigger by activating the nuclear factor-B (NF-B) signaling pathway and NLRP3 (NOD-like receptor protein 3 or NLR family pyrin domain containing 3) inflammasome pathway in endothelial cells both in vitro and in vivo (Seldin et al., 2016

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Pollak 2008) has linked elevated circulating IGF-1 to higher risk of certain cancers in human cohorts

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