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The extract reduced inflammation, axonal swelling, gliosis, and demyelination in the spinal cord

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Many of the observed anti-inflammatory effects may be mediated indirectly through weight loss and improved insulin sensitivity rather than through direct molecular actions

Oxyntomodulin is a biased agonist relative to GLP-1 1,3 (and exendin-P5 26 ), with a bias towards arrestin recruitment over cAMP production, which would compete for G protein interactions and may contribute to the lack of correlation between the faster G s dissociation and enhanced efficacy when assessing cAMP accumulation in whole cells over an extended timeframe