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They are not in the same league on results, and berberine is not a replacement for a prescribed medicine

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GHK-Cu provides direct NRF2/SOD1/catalase antioxidant transcriptome remodelling Tissue specificity: GHK-Cu covers dermal and connective tissue ageing biology

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We slow titration, hold a dose, or step back if your body tells us to

216 A randomized placebo-controlled trial that included 32 healthy Japanese men aged 2029 years found 800 mcg of folic acid plus 8.4 mg of B 2 daily for two weeks reduced homocysteine levels more than B 2 alone and similarly to folic acid alone